Vol. 40 | No. 1 | January-June 2012 Back

Open Access

Myocardial Performance Index Combined with Framingham CHD Risk Score in Determining Angiographic Severity of CAD by Gensini Scoring

Jennifer Doria-Del Castillo, Edwin K. Tiempo, Alex T. Junia, Marivic V. Vestal
Jun 2012 DOI 10.69944/pjc.d912f6f11e

Abstract

OBJECTIVE: The aim of this study was to investigate whether myocardial performance index (MPI) and Framingham Coronary Heart Disease (CHD) score correlated with severity of coronary artery disease (CAD) as assessed by angiography (Gensini scoring), and whether combining the two parameters improved correlation with Gensini scoring. 

STUDY DESIGN: Prospective, cross-sectional association study 

SETTING: Perpetual Succour Hospital-Cebu Heart Institute 

POPULATION: The study included patients suspected to have CAD from June 2011 to February 2012, and had undergone two-dimensional echocardiography and coronary angiography. 

METHODS: After recording pertinent baseline characteristics, each patient’s Framingham CHD Risk Score was calculated. MPI was determined by echocardiography. Coronary angiography was performed by interventional cardiologists blinded to the patient’s Framingham Risk Score and MPI. Severity of the angiographic lesions was determined using Gensini scoring determined by a single angiographer. 

RESULTS: Male sex and alcohol consumption showed correlation with obstructive CAD (p=0.048 and 0.00, respectively). Framingham CHD Risk Score did not show significant correlation with severity of CAD assessed by Gensini score (r=0.118; p=0.332). MPI was moderately correlated with Gensini score (r=0.444; p-value=0.000), indicating a good predictive value in determining severity of CAD. The fitted model plot revealed that combined Framingham CHD Risk Score and MPI added incremental value in predicting severity of significant CAD (squared-multiple R=0.199) 

CONCLUSION: This study shows that Framingham CHD Risk Score alone did not show a correlation with significant CAD. The MPI and combined Framingham CHD risk score showed correlation in determining severity of CAD assessed by Gensini score.

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