Vol. 41 | No. 2 | July-December 2013Back

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A Meta-analysis on the Effects of Tolvaptan in Patients with Chronic Heart Failure

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Philipp C. Ines, MD, Francis Charles L. Fernandez, MD, Francis Carl L. Catalan, MD, Irene L. Celedonio, MD, Florido A. Atibagos, Jr. 

Philippine Heart Center, Quezon City

  1. Hunt, S.A., Abraham, W.T., Chin, M.H., Feldman, A.M., Francis, G.S., Ganiats, T.G., Jessup, M., Konstam, M.A., Mancini, D.M., Michl, K., Oates, J.A., Rahko, P.S., Silver, M.A., Stevenson, L.W., Yancy, C.W., Antman, E.M., Smith, S.C., Adams, C.D., Anderson, J.L., Faxon, D.P., Fuster, V., Halperin, J.L., Hiratzka, L.F., Hunt, S., Jacobs, A.K., Nishimura, N., Ornato, J.P., Page, R.L., and Riegel, B. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult : A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society. Circulation. 2005;112:e154-e235. 
  2. Goldsmith SR. Congestive heart failure: potential role of arginine vasopressin antagonists in the therapy of heart failure. Congest Heart Fail 2002;8:251-6. 
  3. Schrier, R.W., Gross, P., Gheorghiade, M., Berl, T., Verbalis, J.G., Czerwiec, F.S., Orlandi, C. for the SALT Investigators. Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia. N Engl J Med 2006;355:2099-112. 
  4. De Luca L, Klein L, Udelson JE, et al. Hyponatremia in patients with heart failure. Am J Cardiol 2005;96:19L-23L. 
  5. Gheorghiade, M., Konstam, M.A., Burnett, J.C., Grinfeld, L., Maggioni, A.P., Swedberg, K., Udelson, J.E., Zannad, F., Cook, T., Ouyang, J., Zimmer, C., Orlandi, C. For the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) Investigators. Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials. JAMA. 2007 Mar 28;297(12):1332-43. 
  6. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996;17:1-12. 
  7. Gheorghiade, M., Niazi, I., Ouyang, J., Czerwiec, F., Kambayashi, J., Zampino, M., Orlandi, C. Vasopressin V2-Receptor Blockade With Tolvaptan in Patients With Chronic Heart Failure: Results From a Double-Blind, Randomized Trial. Circulation. 2003;107:2690-2696. 
  8. Konstam, M.A., Gheorghiade, M., Burnett, J.C., et al. Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure: The EVEREST Outcome Trial. JAMA. 2007;297(12):1319-1331. 
  9. Udelson, J.E., Bilsker, M., Hauptman, P.J., Sequeira, R., Thomas, I., O’Brien, T., Zimmer, C., Orlandi, C., Konstam, M.A. A multicenter, randomized, double-blind, placebo-controlled study of tolvaptan monotherapy compared to furosemide and the combination of tolvaptan and furosemide in patients with heart failure and systolic dysfunction. J Card Fail. 2011 Dec;17(12):973-81. 
  10. Gheorghiade, M., Gattis, W.A., O’Connor, C.M., Adams, K.F., Elkayam, U., Barbagelata, A., Ghali, J.K., Benza, R.L., McGrew, F.A., Klapholz, M., Ouyang, J., Orlandi, C. Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Congestive Heart Failure (ACTIV in CHF) Investigators Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. JAMA. 2004 Apr 28;291(16):1963-71. 
  11. Matsuzaki, M., Hori, M., Izumi, T., Fukunami, M. For the Tolvaptan Investigators. Efficacy and Safety of Tolvaptan in Heart Failure Patients with Volume Overload Despite the Standard Treatment with Conventional Diuretics: A Phase III, Randomized, Double-blind, Placebo-controlled Study (QUEST Study). Cardiovasc Drugs Ther (2011) 25 (Suppl 1):S33–S45. 
  12. Elkayam, U., Bitar, F., Akhter, M.W., Khan, S., Patrus, S., Derakhshani, M. Intravenous nitroglycerin in the treatment of decompensated heart failure: potential benefits and limitations. J Cardiovasc Pharmacol Ther. 2004;9:227-241. 
  13. Udelson, J.E., Orlandi, C., Ouyang, J., Krasa, H., Zimmer, C.A., Frivold, G., Haught, W.H., Meymandi, S., Macarie, C., Raef, D., Wedge, P., Konstam, M.A., Gheorghiade, M. Acute Hemodynamic Effects of Tolvaptan, a Vasopressin V2 Receptor Blocker, in Patients With Symptomatic Heart Failure and Systolic Dysfunction. J Am Coll Cardiol 2008;52:1540–5.

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