Vol. 46 | No. 2 | July-December 2018Back

Open Access

Effects of HER2 Receptor Antagonist (Trastuzumab And Lapatinib) on Cardiac Chamber Size and Function Measured by Echocardiography Among Early HER2 Positive Breast Cancer Patients in a Tertiary Hospital

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Paul John L. Ablaza, MD; Cresmelita M. Banez, MD; Julie Ann Tapispisan, MD

Sto. Tomas University Hospital, University of Sto. Tomas, Manila

  1. D. Cardinale, A. Colombo, R. Torrisi, et al. Trastuzumab induced cardiotoxicity: clinical and prognostic implications of troponin I evaluation. J Clin Oncol 2010; 28, 3910–3916.
  2. D. Bovelli, G. Plataniotis & F. Roila. Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO Clinical Practice Guidelines. Annals of Oncology 21 (Supplement 5): v277–v282, 2010.
  3. Douraid K. Shakira, Kakil I Rasul. Chemotherapy Induced Cardiomyopathy: Pathogenesis, Monitoring and Management. J Clin Med Res 2009;1(1):8-12.
  4. Perez EA, Koehler M, Byrne J, Preston AJ, Rappold E, Ewer MS. Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc. 2008 Jun;83(6):679-86.
  5. Sendur MA, Aksoy S, Altundag K. Cardiotoxicity of novel HER2- targeted therapies. Curr Med Res Opin. 2013 Aug;29(8):1015-24.
  6. Banchs J, Jefferies JL, Plana JC, et al. Imaging for cardiotoxicity in cancer patients. Tex Heart Inst J 2011;38:268-9.l
  7. Noam F Pondé,1 Matteo Lambertini,1,2 and Evandro de Azambuja. Twenty years of anti-HER2 therapy-associated cardiotoxicity. ESMO Open 2016;1:e000073.
  8. Untch M, Loibl S, Bischoff J et al. Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial. Lancet Oncol 2012;13:135–44.
  9. Robidoux A, Tang G, Rastogi P, et al. Lapatinib as a component of neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41): an open-label, randomised phase 3 trial. Lancet Oncol 2013;14:1183–92.
  10. Baselga J, Bradbury I, Eidtmann H et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet Lond Engl 2012;379:633–40.
  11. Valachis A, Nearchou A, Polyzos NP et al. Cardiac toxicity in breast cancer patients treated with dual HER2 blockade. Int J Cancer 2013;133:2245–52.
  12. Spector NL, Yarden Y, Smith B, et al. Activation of AMP activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proc Natl Acad Sci2007;DOI:10.1073/pnas.0701286104.
  13. Zeglinski M, Ludke A, Jassal DS, Singal PK. Trastuzumab-induced cardiac dysfunction: a ‘dual-hit’. Exp Clin Cardiol. 2011;16(3):70-74.
  14. Sandoo A, Kitas GD, Carmichael AR. Breast cancer therapy and cardiovascular risk: focus on trastuzumab. Vasc Health Risk Manag. 2015;11:223-228.
  15. Ewer MS, Ewer SM. Troponin I provides insight into cardiotoxicity and the anthracycline-trastuzumab interaction. J Clin Oncol. 2010;28(25):3901-3904.
  16. Goldhirsch A, Gelber RD, Piccart-Gebhart MJ, et al; Herceptin Adjuvant (HERA) Trial Study Team. 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet. 2013;382(9897):1021-1028.
  17. Earl HM, Vallier A-L, Dunn J, et al. Trastuzumab-associated cardiac events in the Persephone trial. Br J Cancer. 2016;115(12):1462-1470.

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