Vol. 46 | No. 2 | July-December 2018 Back

Open Access

The Association of Triglyceride/HDL Ratio with In-hospital Mortality in Adult Patients Admitted for Acute Coronary Syndrome in Manila Doctors Hospital

Nina Noreen P. Diansuy, Michelle Andrea Uy-Reyes, Joseph Marc Seguban, Karen Amoloza, Noemi Pestano, Felix Eduardo Punzalan, Bernadette Tumanan Mendoza
Dec 2018 DOI 10.69944/pjc.39852a2411

Abstract

Background: Studies showed that the triglyceride/HDL ratio is a predictor of long-term mortality and (CV) events.  However, the association of the triglyceride/HDL ratio to in-hospital mortality in acute coronary  syndrome (ACS) patients is less studied. This study aimed to determine the association of triglyceride/ HDL ratio taken within four days of admission on in-hospital mortality in adult patients admitted  for ACS.  

Methodology: This was a retrospective cohort study involving adult patients admitted for ACS in Manila Doctors  Hospital from January to December 2015. Only patients with lipid profile determination within  four days of admission were included. The triglyceride/HDL ratio was computed and compared  between survivors and non-survivors until discharge or death.  

Results: There were 132 ACS patients included in the study, with 11 in-hospital mortality. The median total  cholesterol level was 170.15mg/dL (IQR 139.21– 201.08); median LDL was 117.94mg/dL (IQR  85.07- 150.81); median HDL was 40.80mg/dL (IQR 34.80- 53.56) and median triglycerides was  127.88mg/dL (IQR 91.60- 185.85). The triglyceride/HDL ratio of ACS patients was elevated at  3.31 (IQR 2.25- 5.13). In patients with elevated triglyceride/HDL ratio (³2.067), the odds ratio  (OR) for total mortality was 0.48 (95% CI 0.13-1.76) and the OR for CV mortality was 0.66 (95%  CI 0.16-2.74), both of which were not statistically significant. 

Conclusion: Patients with ACS have deranged lipid parameters and elevated triglyceride/HDL ratio. However,  there was no evidence of association of elevated triglyceride/HDL ratio with in-hospital mortality.

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