Vol. 47 | No. 2 | July-December 2019 Back

Open Access

Factors Associated with Reperfusion Lung Injury After Total Correction of Tetralogy of Fallot

Abstract

INTRODUCTION: Reperfusion lung injury (RLI) is one of the most common complications after Tetralogy of Fallot (TOF) correction which leads to prolonged hospitalization and significant  morbidity. This study aimed to investigate the different factors that may be associated with RLI after TOF correction. 

METHODS: All patients who underwent TOF correction from January 2015 to December 2016 in a tertiary cardiovascular referral center were included. Baseline characteristics, echocardiographic and intraoperative findings along with their post-operative course were reviewed. Serial chest radiographs were reviewed and each lung was given a pulmonary edema score prior to and after surgery to determine the presence of RLI. Statistical analysis was performed using Stata SE version 13. Factors associated with RLI were determined using logistic logarithm analysis. The level of significance was set at 5%. 

RESULTS: RLI was present in 41 of 114 (36%) patients after TOF correction. Female sex was associated with the development of RLI (OR 2.9; 95% CI 1.29-6.55; p=0.01). Intraoperative use of propofol was a protective factor, with an OR of 0.24 (95% CI 0.07-0.85, p=0.027). We did not identify a significant association between the occurrence of RLI and the factors that reflect the degree of pulmonary stenosis. 

CONCLUSION: RLI is common after TOF correction. Female sex increases the odds of its occurrence while intraoperative use of propofol is a protective factor. 

KEYWORDS: Tetralogy of Fallot, TOF correction, reperfusion lung injury

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