Vol. 48 | No. 1 | January-June 2020Back

Open Access

Role of ST2 in Predicting Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients who Underwent Percutaneous Coronary Intervention

Jason Roy Bacani, Ronaldo H. Estacio, James Ho Khe Sui
Jun 2020 DOI 10.69944/pjc.e6d69b6159

More Info

Jason Roy Bacani, MD | Ronaldo H. Estacio, MD | James Ho Khe Sui, MD

Philippine Heart Center, Quezon City 

References
  1. The Global Burden of Disease. 2004 update. http://www. who.int/evidence/bod; 2008
  2. Health Indicators, Department of Health Republic of the Philippines website. Available at http://www.doh.gov.ph/kp/ statistics/leading mortality. Accessed June 22, 2008.
  3. Sanada S, Hakuni D, Higgins L, et al. IL-33 and ST2 comprise a critical biome-chanically induced and cardioprotective signalling system. J Clin Invest. 2007; 117 (6): 1538-49 Lee RT. Functional genomics and cardiovascular drug dis-covery. Circulation 2001;104:1441e6.
  4. Weinberg EO, Shimpo M, De Keulenaer GW, MacGillivray C, Tominaga C, Solomon S, et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 2002; 106:2961-66
  5. Januzzi JL Jr, Peacock WF, Maisel AS, Chae CU, Jesse RL, Baggish AL, et al. Measurement of the interleukin family member ST2 in patients with acute dysnea. J Am Coll Cadiol. 2007; 50:607-13.
  6. Feldman AM, Weinberg EO, Ray PE, Lorell BH. Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding. Circ Res 1993; 73:184e92.
  7. Shimpo M, Morrow DA, Weinberg EO, Sabatine MS, Murphy SA, et al. (2004) Se-rum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Circulation 109: 2186–2190. doi:10.1161/01.cir.0000127958.21003.5a
  8. Eggers KM, Armstrong PW, Califf RM, Simoons ML, Venge P, et al. (2010) ST2 and mortality in non-ST-segment elevation acute coronary syndrome. Am Heart J 159:788– 794. doi: 10.1016/j.ahj.2010.02.022
  9. Kohli P, Bonaca MP, Kakkar R, Kudinova AY, Scirica BM, et al. (2012) Role of ST2 in non- ST-elevation acute coronary syndrome in the MERLIN-TIMI 36 trial. Clin Chem 58: 257–266. doi: 10.1373/clinchem.2011.173369
  10. Dhillon OS, Narayan HK, Quinn PA, Squire IB, Davies JE, et al. (2011) Interleu-kin 33 and ST2 in non-ST-elevation myocardial infarction: comparison with Global Registry of Acute Coronary Events Risk Scoring and NT-proBNP. Am Heart J 1163–1170. doi:10.1016/j.ahj.2011.03.025
  11. Erkan Yildirim, Atila Iyisoy, Murat Celik, Uygar Cagdas Yuksel, et.al. The rela-tionship between Gensini score and in-hospital mortality in patients with ST- seg-ment elevation eyocardial infarction. International Journal of Cardiovascular Sci-ences. 2017;30(1):32-41
  12. Christoph Sinning, Lars Lillpopp, Sebastian Appelbaum, Francisco Ojeda , Tanja Zeller, et al. Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application. Clin Res Cardiol. March 2013 102:495–503 DOI 10.1007/s00392- 013-0555-4
  13. Naoto Murakami , Nobuaki Kokubu , Junichi Nishida , Mamoru Hase , Takefumi Fujito , et al, Abstract 15183: Do Two Scoring Systems of Coronary Stenosis, Syntax Score and Gensini Score, Similarly Predict Clinical Outcome After Pci in Patients With Stable Angina Pectoris?. Circulation. March 2018;130:A15183
  14. Yan-Peng Wang Jian-Hua Wang Xiao-Long Wang Jun Yi Liu Fang-Yun Jiang, et al. Roles of ST2, IL-33 and BNP in predicting major adverse cardiovascular events in acute myocardial infarction after percutaneous coronary intervention. Journal of cellular and molecular medicine. June 2017 https://doi.org/10.1111/jcmm.13183
  15. Jongwook Yu, Pyung Chun Oh, Minsu Kim, Jeonggeum Moon, Yae Min Park, et.al. Improved early risk stratification of patients with ST-segment elevation myo-cardial infarction undergoing primary percutaneous coronary intervention using a combination of serum soluble ST2 and NT proBNP. August 2017. https://doi.org/10.1371/journal. pone.0182829
  16. Shahabi V, Moazenzadeh M, Azimzadeh BS, et al. Relationship between serum N-terminal pro brain natriuretic peptide (NT-Pro BNP) level and the severity of coronary artery involvements. J Res Med Sci. 2011; 16: 143–8.
  17. 17. Singh HS, Bibbins-Domingo K, Ali S, et al. N-terminal pro-B-type natriuretic peptide and inducible ischemia in the Heart and Soul Study. Clin Cardiol. 2009; 32:447–53
  18. Sabatine MS, Morrow DA, Higgins LJ, MacGillivray C, Guo W, Bode C, et al. Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial in-farction. Circulation. 2008;117(15):1936–44. pmid:18378613.
  19. Skali H, Gerwien R, Meyer TE, Snider JV, Solomon SD, Stolen CM.Soluble ST2 and Risk of Arrhythmias, Heart Failure, or Death in Patients with Mildly Sympto-matic Heart Failure: Results from MADIT-CRT. J Cardiovasc Transl Res. Oct 31, 2016. PMID: 27798759 DOI: 10.1007/s12265- 016-9713-1
License

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits use, share — copy and redistribute the material in any medium or format, adapt — remix, transform, and build upon the material, as long as you give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-sa/4.0/.