Vol. 50 | No. 2 | July-December 2022 Back

Open Access

Echocardiographic Midterm and Long-term Outcomes After Arterial Switch Operation for d-Transposition of the Great Arteries: A Single-Institution Experience

Abstract

INTRODUCTION: Arterial switch operation is the preferred surgical management for  d-transposition of the great arteries, but it still has long-term complications, which necessitate  continued follow-up of patients. This procedure was first performed in this institution in 1991,  and after three decades, there is a need to evaluate midterm and long-term outcomes in this population. 

METHODS: This is a descriptive study on arterial switch operation patients between January  2010 and March 2019 in this institution. The following parameters were collected through review  of charts and online health records (Medtrack): preoperative clinical data, surgical technique  and immediate postoperative course and complications, echocardiographic results, and current  clinical status. The study was approved by the institutional ethics review board of the hospital. 

RESULTS: Among the 108 patients included in the study, 35 were long-term patients, and 73  were midterm. A total of 27 patients (25%) were lost to follow-up. Among the remaining patients  (n = 81), 76 (94%) were alive. The most common postoperative complications were pulmonary  stenosis (n = 11), aortic regurgitation (n = 24), and aortic dilatation (n = 2). One patient had  reintervention after surgery for severe pulmonic stenosis. Overall survival function was 93.7%  after 5 years (95% confidence interval, 0.81–0.98) and 79.4% after 9 years (95% confidence  interval, 0.46–0.93). 

CONCLUSION: Complications seen in this population are similar to those seen in literature. The  overall survival rate after 5 years compares to those of other institutions. However, long-term  survival rates were lower, which may be due to poor patient follow-up and a high rate of patient  attrition over time. To improve future outcomes, strategies should be implemented to promote  continuity of care, and parents should be advised regarding the importance of follow-up. 

KEYWORDS: arterial switch operation, d-TGA, echocardiography, midterm complications, long term complications, survival rate

  1. Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A. Prevalence of congenital heart defects in metropolitan Atlanta, 1998–2005. J Pediatr 2008;153:807.
  2. Wernovsky G. Transposition of the great arteries. In: Allen HD, Shaddy RE, Driscoll DJ, Feltes TF, eds. Moss and Adams’ Heart Disease in Infants, Children and Adolescents: Including the Fetus and Young Adult. 7th ed. Philadelphia, PA: Wolters Kluwer Health/Lipincott Williams & Wilkins; 2008:1039.
  3. Jaggers J, Cameron DE, Herlong JR, Ungerleider RM. Congenital Heart Surgery Nomenclature and Database Project: transposition of the great arteries. Ann Thorac Surg 2000:69;5205.
  4. Villalbaen C, Lafuente MV, Mouratian M, et al. Arterial switch operation: long term outcome. Rev Argent Cardiol 2016;84:418–425.
  5. Fricke TA, d’Udekem Y, Richardson M, et al. Outcomes of arterial switch operation for transposition of the great arteries: 25 years of experience. Ann Thorac Surg 2012;94:139–145.
  6. Shim M, Jun T, Yang J, et al. Current expectations of the arterial switch operation in a small volume center: a 20-year, single-center experience. J Cardiothorac Surg 2016;11:34–44.
  7. Choi BS, Kwon BS, Kim GB, et al. Long term outcomes after an arterial switch operation for simple complete transposition of the great arteries. Korean Circ J 2010;40(1):23–30. doi: 10.4070/kcj.2010.40.1.23.
  8. Losay J, Touchot A, Serraf A, et al. Late outcome after arterial switch operation for transposition of the great arteries. Circulation 2001;104:I-121–126.
  9. Xiao, Y. Early and mid-term follow up of patients receiving arterial switch operation: a single center experience. J Thorac Dis 2018:10(2);732–739.
  10. Grotenhuis HB, Cifra B, Mertens LL, et al. Left ventricular remodelling in long-term survivors after the arterial switch operation for transposition of the great arteries. Eur Heart J 2019;20:101–107.
  11. Vargo P, Mavroudis C, Stewart RD, Backer CL. Late complications following the arterial switch operation. World J Pediatr Congenit Heart Surg 2011;2:37–42.
  12. Legendre A, Losay J, Touchot-Kone A, et al. Coronary events after arterial switch operation for transposition of the great arteries. Circulation 2003;108 suppl 1:II186–II190.
  13. Khairy P, Clair M, Fernandes SM, et al. Cardiovascular outcomes after the arterial switch operation for d-transposition of the great arteries. Circulation 2013;127:331–339.
  14. Fricke TA, Bulstra AE, Naimo PS, et al. Excellent long term outcomes of the arterial switch operation in patients with intramural coronary arteries. Ann Thorac Surg 2016;101:725–729.
  15. Scognamiglio G, Li W. Arterial switch operation for transposition of great arteries: late results in adult patients. Medicine 2013. doi: 10.17987/icfj.v1i1.13.
  16. Co-Vu JG, Ginde S, Bartz PJ, Frommelt PC, Tweddell JS, Earing MG. Long term outcomes of the neoaorta after arterial switch operation for transposition of the great arteries. Ann Thorac Surg 2013:95;1654–1659.
  17. Martinez MS, Balderas JJ, Cases LSR, Lopez WL. Intermediate term survival and functional results of patients after arterial switch operation. Philippine Heart Center. 2000.
  18. Peacock JL, Peacock PJ. Research design. In: Oxford Handbook of Medical Statistics. New York: Oxford University Press; 2011:60–61.
  19. Hernandez RFR, Nuevo J, Cantre T, Casas MLS. Prognostic scoring index to predict outcome of arterial switch operation in Filipino children. Phil Heart Ctr J. 2003;10:50–60.
  20. Prifti E, Crucean A, Bonacchi M, et al. Early and long term outcome of the arterial switch operation for transposition of the great arteries: predictors and functional evaluation. Eur J Cardiothorac Surg 2002;22(6):864–873.
  21. Villafañe J, Lantin-Hermoso MR, Bhatt AB, et al. d-Transposition of the great arteries: hot topics in the current era of the arterial switch operation. J Am Coll Cardiol 2014;64(5):498–511.
  22. Lalezari S, Bruggemans EF, Blom NA, Hazekamp MG. Thirty-year experience with the arterial switch operation. Ann Thorac Surg 2011;92:973–979.
  23. Feng B, Yinglong L, Hu S, et al. Arterial switch for transposition of the great vessels and Taussig-Bing anomaly after six months of age. Ann Thorac Surg 2009;88:1948–1951.
  24. Sarris GE, Chatzis AC, Giannopoulos NM, et al. The arterial switch operation in Europe for transposition of the great arteries: a multi-institutional study form the European Congenital Heart Surgeons Association. J Thorac Cardivasc Surg 2006;132:633–639.
  25. Duncan BW, Poirier NC, Mee RBB, et al. Selective timing of the arterial switch operation. Ann Thorac Surg 2004;77:1691–1697.
  26. Delmo Walter EM, Miera O, Nasseri B, et al. Onset of pulmonary stenosis after arterial switch operation for transposition of great arteries with intact ventricular septum. HSR Proc Intensive Care Cardiovasc Anesth 2011;3(3):177–187.
  27. van der Palen RL, van der Bom T, Dekker A, et al. Progression of aortic dilatation and aortic valve regurgitation after the arterial switch operation. Heart 2019;105:1732– 1740.
  28. Hutter PA, Thomeer BJM, Jansen P, et al. Fate of the aortic root after arterial switch operation. Eur J Cardiothorac Surg 2001;20:82–88.
  29. Michalak KW, Moll JA, Sobczak-Budlewska K, et al. Reoperations and catheter interventions in patients with transposition of the great arteries after arterial switch operation. Eur J Cardiothor Surg 2017;51:34–42.
  30. Fricke TA, Donaldson S, Schneider JR, et al. Outcomes of the arterial switch operation in patients with aortic arch obstruction. J Thorac Cardiovasc Surg 2020;159(2):592– 599.

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