Development of a Clinical Pathway for Acute Coronary Syndrome at Philippine General Hospital
Abstract
BACKGROUND: Acute coronary syndrome (ACS) is a leading cause of admission and mortality in a tertiary care hospital in the Philippines. The significant burden of the disease necessitates that evidence-based care set by international and local guidelines be met to improve service delivery and quality of care (QOC). Institution-specific QOC studies showed gaps between guideline recommendations and compliance. Development and utilization of a clinical pathway are among the identified strategies to improve compliance. It is also crucial for implementation of standard-of-care set specific to a hospital setting based on its needs and resources.
METHODS: This is a descriptive research on the development of a clinical pathway for ACS appropriate for the emergency room setting of a tertiary care hospital from March 2021 to August 2022. Local QOC studies and evidence behind the latest international guideline recommendations on the management of ACS were reviewed to create the interim ACS Pathway. Two-level content validation of the interim pathway was done: internal validation with the consultants and fellows of the Division of Cardiovascular Medicine and external validation through focused group discussions with different hospital units and stakeholders to assess applicability and feasibility based on the resources of the setting, identify hindrances, and propose solutions in its implementation.
RESULTS: An evidence-based clinical pathway for ACS that encompasses identification and management of ST-segment elevation myocardial infarction and non–ST-segment elevation acute coronary syndrome with judicious use of locally available and feasible resources applicable for local emergency room hospital setting was created.
CONCLUSION: Review of local QOC studies and interdepartmental collaboration are necessary components in developing institution-specific clinical pathway for ACS.
KEYWORDS: acute coronary syndrome, clinical pathway, quality of care
- World Health Organization. Cardiovascular Diseases. Geneva, Switzerland: WHO; 2021.
- Department of Health. The 2018 Philippine Health Statistics. 2018
- Roque VL, Besa JJ, Medina H, Nicolas A, Magnaye FM. 2019 Ward Services Year-End Report. 2020. Internal document.
- Jneid H, Addison D, Bhatt, DL, et al. 2017 AHA/ACC clinical performance and quality measures for adults with ST-elevation and non–ST-elevation myocardial infarction: a report of the American College of Cardiology/ American Heart Association Task Force on Performance Measures. Circulation 2017;10(10).
- Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2018;39(2):119–177.
- Collet JP, Thiele H, Barbato E, et al. 2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2021;42(14):1289–1367.
- Biviano AB, Rabbani LRE, Paultre F, et al. Usefulness of an acute coronary syndrome pathway to improve adherence to secondary prevention guidelines. Am J Cardiol 2003;91(10):1248–1250. doi:10.1016/S0002- 9149(03)00276-5.
- Mehta RH, Montoye CK, Gallogly M, et al. Improving quality of care for acute myocardial infarction: the Guidelines Applied in Practice (GAP) initiative. J Am Med Assoc 2002;287(10):1269–1276. https://doi.org/10.1001/ jama.287.10.1269.
- Ozdas A, Speroff T, Waitman L, et al. Integrating “best of care” protocols into clinicians’ workflow via care provider order entry: impact on quality-of-care indicators for acute myocardial infarction. J Am Med Inform Assoc 2006;13(2):188–196. doi:10.1197/jamia.M1656.
- Punzalan FE, Lim-Quianzon D, Pestano N, et al. The quality of care of patients with acute myocardial infarction in the University of the Philippines—Philippine General Hospital. 1999. Internal report.
- Obrado M, Punzalan F, Tranquilino F, Reyes E. Pattern of physicians in the in-hospital Management of acute coronary syndrome and their compliance to existing guidelines; a quality of care study. 2008. Internal report.
- Magno JD, Santella C, Punzalan FE. Timely rhythm assessment for chest pain at the emergency room (TRACER). UP-PGH Cardiovascular Section. 2010. Internal report.
- Alcover JD, Punzalan FE, Reyes EB. Quality of care for acute coronary events at the Philippine General Hospital emergency room: a two-month study. UP PGH Cardiovascular Research Compendium 2012;1(1).
- Lim K, Chan M. Quality of care assessment of the management of St-elevation myocardial infarction in patients admitted in the Philippine General Hospital. 2018. Internal report.
- Ramiro V, Tiongson M, Taquiso J et al. Quality of care assessment of adult patients with ST-elevation myocardial infarction at the emergency room of a tertiary hospital in the Philippines. 2019. Internal report.
- Reymatias J, Tiongson MD, Evangelista LK, Reganit PF, Punzalan FER. Quality of care in adult patients with non– ST-segment elevation acute coronary syndrome at the University of the Philippines—Philippine General Hospital Emergency Room. 2019. Internal report.
- Evangelista LKE, et al. Compliance of physicians at a tertiary hospital in the Philippines to the ST-elevation myocardial infarction pathway. 2019. Internal report.
- Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non–ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;64(24):e139–e228.
- O’Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/ AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2013;127(4):e362–e425.
- Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009;361(11):1045–1057.
- Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357(20):2001–2015.
- Mehta SR, Granger CB, Eikelboom JW, et al. Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the OASIS-5 trial. J Am Coll Cardiol 2007;50(18):1742–1751.
- Yusuf S, Mehta SR, Chrolavicius S, et al. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. JAMA 2006;295(13):1519– 1530.
- Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med 2015;372(25):2387–2397.
- Sabatine MS, Giugliano RP, Keech AC, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med 2017;376(18):1713–1722
- Shrivastava AK, Singh HV, Raizada A, Singh SK. Serial measurement of lipid profile and inflammatory markers in patients with acute myocardial infarction. EXCLI J 2015;14:517–526.
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