Vol. 52 | No. 2 | July-December 2024Back

Open Access

Cardiovascular Profile of Patients With COVID-19 Infection Admitted in a Tertiary Care Hospital in Manila, Philippines: A 2-Year Single-Center Retrospective Study

More Info

Reynald Evan R. Tugade, MD* | Edgar Y. Ongjoco, MD* | Manolito M. Turalba, MD* | Antonio Yabon II, MD | Nichole Andrea N. Bisquera, MD | Leonico C. Gonzales, MD | Donna Aurea L. Maderazo, MD* | Alyssa Maxine V. Santos, MD* | Eleazar T. Suguitan, MD

* HB Calleja Heart and Vascular Institute, St Luke’s Medical Center, Quezon City, Philippines
Department of Medicine, St Luke’s Medical Center, Quezon City, Philippines

Correspondence:
Reynald Evan R. Tugade, MD
Unit No. 16 Cathedral Heights, E. Rodriguez, Quezon City, Philippines
Email: reynaldevan@gmail.com; rertugade@stlukes.com.ph

The authors have no financial interest or affiliation concerning the materials discussed.

  1. Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19). https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html. Accessed April 11, 2020.
  2. Chan JF, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet (London, England) 2020;395(10223):514–523. doi:10.1016/S0140-6736(20)30154-9.
  3. Inciardi RM, Lupi L, Zaccone G, et al. Cardiac Involvement in a Patient with Coronavirus Disease 2019 (COVID-19). J Am Med Assoc 2020;5(7):819–824 . doi:10.1001/jamacardio.2020.1096.
  4. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506. doi:10.1016/S0140-6736(20)301835.
  5.  Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004;203(2):631–637.
  6. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020;579(7798):270–273.
  7. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054–1062.
  8. Chousterman BG, Swirski FK, Weber GF. Cytokine storm, and sepsis disease pathogenesis. Semin Immunopathol 2017;39(5):517–528.
  9. Shi S, Qin M, Shen B, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol 2020;5(7):802-810. doi:10.1001/jamacardio.2020.0950.
  10. Madjid M, Miller CC, Zarubaev VV, et al. Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: results from 8 years of autopsies in 34,892 subjects. Eur Heart J 2007;28(10):1205–1210. doi:10.1093/eurheartj/ehm035.
  11. Madjid M, Connolly AT, Nabutovsky Y, Safavi-Naeini P, Razavi M, Miller CC. Effect of high influenza activity on risk of ventricular arrhythmias requiring therapy in patients with implantable cardiac defibrillators and cardiac resynchronization therapy defibrillators. Am J Cardiol 2019;124(1):44–50. doi:10.1016/j.amjcard.2019.04.011.
  12. Kytömaa S, Hegde S, Claggett B, et al. Association of influenza-like illness activity with hospitalizations for heart failure: the Atherosclerosis Risk in Communities Study. JAMA Cardiol 2019;4(4):363–369. doi:10.1001/jamacardio.2019.0549.
  13. Hanif A, Khan S, Mantri N, et al. Thrombotic complications and anticoagulation in COVID-19 pneumonia: a New York City hospital experience. Ann Hematol 2020;99(10):2323–2328.
  14. Madjid M, Miller CC, Zarubaev VV, et al. Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: results from 8 years of autopsies in 34,892 subjects. Eur Heart J 2007;28(10):1205–1210. doi:10.1093/eurheartj/ehm035.
  15.  Mehra MR, Desai SS, Kuy S, Henry TD, Patel AN. Cardiovascular disease, drug therapy, and mortality in COVID-19. N Engl J Med 2020:382(25):e102. doi:10.1056/NEJMoa2007621.
  16. Long B, Brady WJ, Koyfman A, Gottlieb M. Cardiovascular complications in COVID-19. Am J Emerg Med 2020;38(7):1504–1507. doi:10.1016/j.ajem.2020.04.048.
  17. Chen T, Wu D, Chen H, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ (Clinical Research Ed) 2020;368:m1091. doi:10.1136/bmj.m1091.
  18. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA 2020;323(11):1061–1069. doi:10.1001/jama.2020.1585.
  19. Xu H, Martin A, Singh A, et al. Pulmonary embolism in patients hospitalized with COVID-19 (from a New York Health System). Am J Cardiol 2020;133:148−153.
  20. Basu-Ray I, Soos MP. Cardiac manifestations of coronavirus (COVID-19) [updated April 12, 2020]. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2020. https://www.ncbi.nlm.nih.gov/books/NBK556152/.
  21. Rosenberg ES, Dufort EM, Udo T, et al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State [published online May 11, 2020]. JAMA 2020;323(24):2493–2502. doi:10.1001/jama.2020.8630.
  22. Sacher F, Fauchier L, Boveda S, et al; Working Group of Pacing, Electrophysiology of the French Society of Cardiology, the Board of the French Society of Cardiology. Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection. Arch Cardiovasc Dis 2020;113(5):293–296. doi:10.1016/j.acvd.2020.04.003.
  23. Ma L, Song K, Huang Y. Coronavirus disease 2019 (COVID-19) and cardiovascular complications. J Cardiothorac Vasc Anesth 2021;35(6):1860–1865. doi:10.1053/j.jvca.2020.04.041.
  24. Longchamp G, Blondon M. Proximal deep vein thrombosis and pulmonary embolism in COVID-19 patients: a systematic review and meta-analysis. PROSPERO International Prospective Register of Systematic Reviews (CRD42020193369). Thromb J 2021;19:15. doi:10.1186/s12959-021-00266-x.

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits use, share — copy and redistribute the material in any medium or format, adapt — remix, transform, and build upon the material, as long as you give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc-sa/4.0/.