Vol. 52 | No. 1 | January-June 2024

January-June 2024

Open Access
The Words of the Year: Rizz, Hallucinate, Artificial Intelligence, and Authentic

Since the year 1972, several organizations have assigned “words of the year” or WOTY to define what is considered the most important word of the year, basically reflecting the theme or expression that best describes the year that was. It can be a cultural phenomenon, a controversy, an influential concept, or a popular thought. This WOTY is voted upon by linguists and lexicographers and the bodies that designate these include the American Dialect Society, Cambridge University for the Cambridge Dictionary, Collins English Dictionary, Dictionary.com, Macquarie Dictionary, Merriam Webster, and Oxford University Press for the Oxford Dictionary, among others.

Open Access
2023 Philippine Working Group Consensus Statement on Renal Denervation Therapy for the Management of Hypertension

Hypertension is the most common risk factor for cardiovascular disease in the Philippines. Despite the availability of antihypertensive medications that are effective, safe, and tolerated by Filipino patients, the numbers of uncontrolled hypertensives are still increasing. Several factors play in the poor control of blood pressure, particularly resistant hypertension and hyperactive sympathetic nervous system.

Open Access
When Hypertension Gets On One’s Nerves: Has The Time Come For Renal Denervation?

For centuries, hypertension (HTN) has been a major cause of cardiovascular morbidity and mortality. Even now in 2024, despite all the advances in its understanding, adequate diagnosis and treatment of HTN globally is still sorely lacking. In a 2022 publication it is estimated that as much as 54% of hypertensive patients worldwide are undiagnosed. 42% of the hypertensive patients are both diagnosed and treated, yet only 21% of all hypertensive patients have blood pressure (BP) under control(1).

Obviously, on a global scale there are way too many factors and variables that need to be addressed. Yet as practicing clinical physicians we are left to do what we can for the patients we encounter. Assuming there is a program in place to ensure compliance and follow-up, it is estimated that 82% of patients can achieve target BP(2). By simple calculation however, that also means nearly 20% of compliant patients will still not achieve target BP levels despite adequate medical treatment. And amongst those who do, around 20% would be on 3 or 4 anti hypertensive agents(3). This then begs the question… what else can we do for these difficult-to control patients?

Open Access
The Correlation of Platelet-to-Lymphocyte Ratio Levels With Clinical Outcomes in Acute Coronary Syndrome Patients Admitted in a Tertiary Hospital From January 2011 to December 2020
The Correlation of Platelet-to-Lymphocyt

Studies have shown that inflammation plays a role in the pathogenesis of acute coronary syndrome (ACS). The use of platelet-to-lymphocyte ratio (PLR) as a marker for inflammatory conditions such as malignancy, systemic lupus erythematosus, and rheumatoid arthritis has been demonstrated in several studies. The aim of this study is to determine whether an elevated PLR taken on admission is associated with in-hospital mortality and major adverse cardiac events among ACS patients.

Open Access
Impact of Age, Sex, and Cardiovascular Disease in Mortality in COVID-19 at the Medical City
Impact of Age, Sex, and Cardiovascular D

COVID-19 (coronavirus disease 2019), which is caused by the human severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), has reached a pandemic level. As a novel disease, local epidemiologic data are important to determine high-risk age groups, as well as risk factors that contribute to mortality. This study is a retrospective cohort study of 182 COVID-19–positive patients confirmed by real-time polymerase chain reaction.

Open Access
Efficacy and Safety of Sacubitril/Valsartan in Adverse Cardiovascular Event Reduction and Hypertension Control Among Asians: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Efficacy and Safety of Sacubitril/Valsar

Sacubitril/valsartan is currently a standard medication in the treatment of reduced ejection fraction heart failure (HFrEF), and studies have also shown its efficacy for controlling hypertension. However, its efficacy varies between populations, and current recommendations are predominantly based on non-Asian data. Hence, this study synthesizes the available evidence to determine its overall efficacy and safety among Asians.

Open Access
The Association of Withdrawing Maintenance Renin-Angiotensin System Inhibitor on All-Cause Mortality and Intensive Care Unit Admission Among Hypertensive Patients Admitted for Mild to Moderate COVID-19 infection:A Meta-analysis of Observational Studies
The Association of Withdrawing Maintenan

The pandemic caused by coronavirus disease 2019 (COVID-19) posed a serious challenge to all health care systems in the world. It has been found to be harmful in people with underlying cardiovascular diseases, particularly in patients with systemic hypertension, which may be due to upregulation of angiotensin-converting enzyme 2 (ACE2) expression, which may lead to increased severe acute respiratory syndrome coronavirus 2 virulence. Renin-angiotensin system inhibitor (RASI) acts by blocking the angiotensin-converting enzyme and angiotensin II type 1 receptors, which in turn affects the production of the ACE2 protein. Hence, there have been arguments on whether to continue or discontinue this medication. Given the widespread use of RASIs globally and the fact that they are generally cardioprotective, research into the safety of continuing these maintenance medications in patients hospitalized with mild to moderate COVID-19 is immensely needed.

Open Access
Lutembacher Syndrome in a 35-Year-Old Filipino Woman: A Case Report
Lutembacher Syndrome in a 35-Year-Old Fi

Lutembacher syndrome (LS) is an uncommon cardiac abnormality characterized by any association of a congenital or iatrogenic atrial septal defect (ASD) and a congenital or acquired mitral stenosis (MS). The hemodynamic effects of this syndrome are a result of the interplay between the relative effects of the ASD and MS.

Open Access
Tangled: Unraveling a Rare Combination of Multiple Coronary Artery Fistulas and Severe Aortic Stenosis in a 70-Year-Old Man
Tangled: Unraveling a Rare Combination o

Coronary artery fistulas (CAFs) are rare congenital or acquired anomalies that connect one or more coronary arteries to a cardiac chamber or a great vessel without an intervening capillary bed. Most are asymptomatic and are usually incidental findings on echocardiography or angiography for an unrelated cause. Occasionally, complications occur, which include endocarditis, thrombosis, steal syndrome, and heart failure.Here, we present a rare case of multiple CAFs draining to the main pulmonary artery in a patient with severe aortic stenosis (AS) presenting a unique management dilemma.

Open Access
Development of a Clinical Pathway for Acute Coronary Syndrome at Philippine General Hospital

Acute coronary syndrome (ACS) is a leading cause of admission and mortality in a tertiary care hospital in the Philippines. The significant burden of the disease necessitates that evidence-based care set by international and local guidelines be met to improve service delivery and quality of care (QOC). Institution-specific QOC studies showed gaps between guideline recommendations and compliance. Development and utilization of a clinical pathway are among the identified strategies to improve compliance. It is also crucial for implementation of standard-of-care set specific to a hospital setting based on its needs and resources.

Open Access
The Heartbeat: Evidence and Presupposition from Days of Yore and Far Yonder

Let we, who are supposed experts of the heart and know that there’s a tiny node at the roof of the right atrium that fires impulses automatically to the demand of the body with nary our care or intent, pause for a moment to appreciate what it took for our forefathers to put us in this position of knowledge; and, by the same awareness, be humbled to realize that there’s a lot more beyond what we know and understand.